医学免疫学课件08－Antigen-Presenting Cells and Antigen Presentation.pptVIP

Processing of Class I and Class II vs CD1 Antigens * 分泌功能： -产生溶酶体酶、髓过氧化物酶、活性氧等，与杀伤和抗原处理有关 -分泌细胞因子、补体、凝血因子等，与炎症反应有关； -产生前列腺素、白三烯、ACTH、内啡肽等，与免疫调节有关。 * 促炎细胞因子：TNF-alpha, IL-1, IL-6, IL-8, 参与局部和全身的炎症反应。 * BCR摄取抗原，在抗原浓度低的情况下，有效摄入和递呈，显示浓缩抗原效应。主要摄取可溶性抗原。 * 递呈抗原的来源与抗原处理和递呈途径及诱导的免役应答类型密切相关。 * The intracellular replication takes place in cytosolic compartment and these pathogens are processed by endogenous processing pathway. The pathogens are for example viral antigens.The tumor antigens also use this pathway for processing.. extracellular replication or endosomal replication take place in extrace