毛细管电泳分析法在药物分析中的应用.docxVIP

毛细管电泳分析法在药物分析中的应用 摘要 毛细管电泳技术又称为高效毛细管电泳。作为一种新的分离分析技术，以其高效, 快速，低实验消耗等优点，受到了广泛重视，而其在药物分析中的应用得到迅速的发 展。在原料分析中的中药材鉴别和质量控制，中药有效成分的分离与测定和中成药制 剂。而在西药复方制剂中，广泛用于解热镇痛药、抗组胺药、消炎药和止咳药，降压 药和抗生素、合成抗菌剂及生物技术产品等药物和制剂的分离，鉴定和分析及其对手 性分子的拆分，基于手性主一客体络合的毛细管电泳手性拆分，基于手性胶束增溶的 毛细管电泳手性拆分和基于蛋白质亲和的毛细管电泳手性拆分，还有临床用药中，都 显示了其高效，快速的特点。毛细管电泳技术正广泛用于药物分析的各个相关的部分 中，正越来越受到人们的重视。 Abstract Capillary electrophoresis technology called high performance capillary electrophoresis. As a new kind of separation and analysis technology, with its rapid, efficient, low consumption advantages of experiment was Received widely attention, and its application in pharmaceutical analysis is rapid development. The analysis of Chinese herbal medicine in raw material identification and quality control, the TCM separation and determination and proprietary Chinese medicine preparations. But in western medicine compound preparations, widely used in antipyretic analgesics, the antihistamine drugs, expectorant and cough, antihypertensives and antibiotics, synthetic antibacterial agent and biotechnology product such drugs and preparation of separation, appraisal and analysis and the opponent of chiral molecule split, based on chiral Lord - object complexation of capillary electrophoresis chiral resolution, based on chiral dissociation of increase soluble adopted capillary electrophoresis chiral separation and based on protein affinitive capillary electrophoresis chiral resolution, and clinical medicine, shows its high efficiency, fast characteristic. Capillary electrophoresis technology is widely used in pharmaceutical analysis of each relevant sections, are becoming more and more attention by people. 关键词：毛细管电泳技术药物分析应用 关键词：毛细管电泳技术 药物分析 应用 Keywords: Capillary electrophoresis drug analysis application 前言 毛细管电泳(CE)又称为高效毛细管电泳(high performance capillary electrophoresis, HPCE),它以弹性石英毛细血管为分离通道，以高压直流电场为驱动力，依据样品中各组分 的淌度和分配行为上的差别进行分离和分析。[1] 一毛细管电泳分析的特点 CE是八十年代后期在全球范围内迅速崛起的一种分离分析技术。具有快速、高效、高 灵敏度、易定量、重现性好及自动化等优点，已广泛地应用于小分子、小离子、多肽及蛋白 质的分离分析研究。它又在核