体内转染(Entranster)和神经病理性疼痛的研究文献.docVIP

1 23Long Non-coding RNA BC168687is Involved in TRPV1-mediated 4Diabetic Neuropathic Pain in Rats 5Chenglong Liu,a Congcong Li,b Zeyu Deng,a Errong Du a and Changshui Xu a ,c * 6a Department of Physiology,Basic Medical College of Nanchang University,PR China processes, We observed streptozotocin expres-series of molec-(IL-1b in rat protein blot (WB.We Expression of of lncRNA in DRG were diabetic 26the eti-27et al.,2829type 1(TRPV130may be a critical 31pain 32et al.,2014;33are activated by 34and chemical 35in small and 36ganglia (DRG,37ganglia (TG38Spicarova and 392013.The 40struc-41with each 42pore (Palazzo 43(ATPactivates 44between ankyrin 45have shown that 46in models of 47in generation 48et al.,2005;49Premkumar and Sikand,2008;Huang et al.,2013;Brito 50 et al.,2014;Morales-Lazaro et al.,2016.In addition, /10.1016/j.neuroscience.2018.01.049 0306-4522/ó2018IBRO.Published by Elsevier Ltd.All rights reserved. system;SGCs,satellite glial cells;siRNA,small interfering RNA;STZ,streptozotocin;TNF,tumor necrosis factor;TRPV1,transient receptor potential vanilloid type 1;TWL,thermal withdrawal latencies. N EUROSCIENCE RESEARCH ARTICLE C.Liu et al./Neuroscience xxx (2018xxx–xxx 1 Please cite this article in press as:Liu C et al.Long Non-coding RNA BC168687is Involved in TRPV1-mediated Diabetic Neuropathic Pain in Rats.Neuroscience (2018,/10.1016/j.neuroscience.2018.01.049 51P2X receptors are known for their roles in the central and 52PNSs.Activated purinergic P2X receptors contribute to 53neuropathic pain by releasing ATP(Hanani,2012; 54Huang et al.,2013;Brito et al.,2014.Thus,sensitization 55of TRPV1and P2X receptors may lead to chronic in?am-56matory pain and peripheral neuropathy in diabetes 57(Premkumar and Sikand,2008;Brederson et al.,2013; 58Kaneko and Szallasi,2014;Chiba et al.,2017. 59Long noncoding RNAs(LncRNAsare non-protein-60coding RNA transcripts longer than200nucleotides that 61participate in various biological processes and diseases 62(Ponting et al., 63