不同等级2所医院新生儿卡介苗接种效果及影响因素研究.pdf

不同等级 2 所医院新生儿卡介苗接种效果及影响因素研究 史太平,陈鸣，张霞，顾昕，张兴 （常州市疾病预防控制中心，江苏常州 213002） 摘要：目的 了解常州市不同等级的2 所医院新生儿卡介苗接种效果及其影响因素，为提 高接种质量和人群免疫水平提供依据。方法 选择 1 个市级医院、1 个县级医院作为哨点， 监测 2013 年 1～12 月不同批次菌苗对符合条件新生儿的接种情况，3 个月后进行结核菌 素试验试验(PPD)，观察硬结纵横径和直径，评价接种效果；采用Logistic 回归模型，对 接种效果进行多因素回归分析。 结果 共接种卡介苗新生儿 2254 例，接种成功 2090 人， 接种成功率 92.7% 。单因素分析显示，不同单位、季节、疫苗批次卡介苗接种成功率差异 有统计学意义(P0.05) ；金坛市人民医院接种成功率为95.15%，明显大于市妇幼保健院 90.17%，差异有统计学意义(P 0.05); 经组间比较，秋季接种成功率明显高于冬季 2 （χ=14.080, P = 0.000）。疫苗批号201003a015-1 接种成功率明显低于其他各批号， 批号 201003a012-2 接种成功率明显低于批号 201101a004-1 和 201012a083-2 ，差异均有统 计学意义（均 P = 0.000）。多因素logistic 回归分析，疫苗批号(OR=1.754，95%CI ： 1.477~2.084)是卡介苗接种成功的影响因素。 结论 常州市市县不同等级医院新生儿卡介 苗接种成功率均较高，疫苗不同批次是影响接种成功的影响因素。 关键词：新生儿；卡介苗接种；免疫效果；影响因素 Effect and influence factors of neonatal BCG vaccination of two hospitals in Changzhou SHI Tai-ping,CHEN Min,ZHANG Xia,GU Xin,ZHANG Xin. Changzhou center for disease provention and control, Changzhou,Jiangsu 213002,China. Abstract ：Objective To explore the effect and influence factors of neonatal BCG vaccination of two hospitals in Changzhou and improve BCG vaccination quality and immune level. Method two different grade hospitals were collected as sentinel point to supervise BCG vaccination effect for newborns receiving various batches of BCG from Jan. to Dec. 2013. Participants were conducted PPD 3-months after BCG vaccination and were observed vertical and horizontal diameter of BCG harden to assess vaccination effect. Influence factors were analyzed by Logistic aggression. Results A total of 2254 cases of neonatal BCG vaccination were observed and the rate of the vaccination success was 92.7%. Univariate analysis showed that different units, season, vaccine batch were the factors influencing BCG vaccination success (P 0.05); the vaccination success rate of Jintan Peoples Hospital was 9