微生物学通报肠道病原菌III型分泌系统效应蛋白调控宿主细胞NF.pdfVIP

微生物学通报 Oct. 20, 2019, 46(10): 2763−2771 Microbiology China DOI: 10.13344/j.microbiol.china.180823 tongbao@ /wswxtbcn 专论与综述 肠道病原菌 III 型分泌系统效应蛋白调控宿主细胞 NF-κB 和 MAPK 信号通路的研究进展 1 1 1 1 1 *1,2,3 朱平 吕均 薛娟 杨瑾 孟昆 李姗 1 十堰市太和医院(湖北医药学院附属医院) 感染与免疫性疾病研究所 湖北 十堰 442000 2 华中农业大学生命科学技术学院 湖北 武汉 430070 3 华中农业大学生物医学中心 湖北 武汉 430070 摘 要：病原细菌感染对人类健康构成了严重的威胁，一类具有 III 型分泌系统(Type III secretion system，T3SS)的肠道致病细菌可以通过T3SS 将效应蛋白“注射”到宿主细胞中，模拟和操纵宿主细 胞的多种信号转导通路，包括细胞凋亡、细胞自噬和炎症反应等，从而有效地逃逸宿主的防御，增 强感染性和致病性。本文综述了肠道病原菌T3SS 效应蛋白在调控宿主炎症反应中NF-κB 和MAPK 通路的最新研究进展。 关键词：III 型分泌系统，效应蛋白，炎症反应，NF-κB ，MAPK Research progress in regulating host NF-κB and MAPK pathways by the type III secretion system (T3SS) effectors of intestinal pathogenic bacteria ZHU Ping1 LÜ Jun 1 XUE Juan1 YANG Jin 1 MENG Kun 1 LI Shan*1,2,3 1 Institute of Infection and Immunity, Taihe Hospital (Hubei University of Medicine), Shiyan, Hubei 442000, China 2 College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China 3 Bio-Medical Center, Huazhong Agricultural University, Wuhan, Hubei 430070, China Abstract: Pathogenic bacterial infection poses a serious threat to human health. Intestinal pathogenic bacteria that contain a Type III secretion system (T3SS) can use the T3SS to inject effectors into host cells and manipulate multiple signaling pathways, including apoptosis, autophagy and inflammatory responses pathways, in order to evade host defense system and enhance their infectivity and pathogenicity. Here, we have reviewed the latest research progress in the regulation of host NF-κB and MAPK pathways involved in inflammatory responses by the T3SS