立克次体分类研究进展和新分类.pptVIP

立克次体分类研究进展与新分类 昆明医科大学热带医学研究所 病原生物学与免疫学系 宝福凯 教授 电话：0871－5338884 E-mail: baofukai@126.com， Fukai.bao@ 实验室网页：/home Howard Taylor Ricketts (1871-1910) was an American pathologist after whom the Rickettsiaceae family and the Rickettsiales are named. In the earlier part of his career, Ricketts undertook research at Northwestern University on blastomycosis and later at the University of Chicago on and Rocky Mountain spotted fever. Ricketts and his assistant discovered that the agent that carried the bacillus for the latter was the Rocky Mountain wood tick (the American dog tick is also a carrier). Ricketts was devoted to his research and, on several occasions, injected himself with a pathogen in order to measure its effects. In 1909, Ricketts became interested in typhus due to an outbreak in Mexico City and the apparent similarity of the disease to spotted fever. days after isolating the organism that he believed caused typhus, he himself died of the disease. 立克次体目（Rickettsiales）微生物是一类严格细胞内寄生的原核细胞型微生物，其生物学性状如形态结构、化学组成及代谢方式等方面与细菌类似。立克次体是引起斑疹伤寒、恙虫病、Q热等传染病的病原体，首先由美国青年医师 Howard Taylor Ricketts发现，为纪念他在研究斑疹伤寒时不幸感染而献身，故以他的姓名命名。立克次体与节肢动物关系密切，寄生在吸血节肢动物体内，使其成为寄生宿主，或为储存宿主，或同时为传播媒介。立克次体大多是人兽共患病的病原体,引起的新现和再现传染病（Emerging and re-emerging infectious diseases）呈世界性或地方性流行，日益受到医学界重视。 2. Rickettsiology: Present and Future Directions Annals NYAS, Volume 990, Jun 2003 ISBN 1-57331-445-5 770 pages, 46 papers Rickettsiology: Current Issues and Perspectives Annals NYAS，Volume 590, Jun 1990 3. Century of Rickettsiology: Emerging, Reemerging Rickettsioses, Molecular Diagnostics, and Emerging Veterinary Rickettsioses Annals NYAS, Volume 1078, published Oct 2006 Edited by Karim E. Hechemy ; José A. Oteo; Didier A. Raoult, et al. 4. Rickettsioses: From Genome to Proteome, Pathobiology, and Rickettsiae as an International Threat Annals NYAS, Volume 1063, published Feb 2006 Edited by Karim E. Hechemy; José A.