igtcr基因重排原理及多样性.pptxVIP

Ig gene rearrangement in antibody producing cells - Southern blot analysis non lymphoid cell : V,C in the distant fragments mature B cell : V,C in the same fragments ? somatic recombination Figure 4.1 - V gene rearrangement Figure 4.2 V region of light chain : V gene segment (VL protein) (VL gene) J gene segment (JL gene) V region of heavy chain : V gene segment (VH protein) (VH gene) D gene segment (DH gene) J gene segment (JH gene)- The numbers of functional gene segments for the V region of human heavy and light chains ′ pseudogenes ′ :