【课件】药物化学导论（Introduction to Medicinal Chemistry）.docx

10/16/2010 10/16/2010 PAGE PAGE 100 Introduction to Medicinal Chemistry Introduction to Medicinal Chemistry Dr. Majdi Bakhaitan Assistant professor medicinal chemistry HYPERLINK ".sa/mmbakhaitan" .sa/mmbakhaitan HYPERLINK "mailto:mmbkhaitan@.sa" mmbkhaitan@.sa HYPERLINK "/" Medicinal chemistry is the design and synthesis of novel drugs, based on an understanding of how they work at the molecular level. A useful drug must interact with a molecular target in the body (Pharmacodynamics) and also be capable of reaching that target (Pharmacokinetics). Medicinal chemistry is the design and synthesis of novel drugs, based on an understanding of how they work at the molecular level. A useful drug must interact with a molecular target in the body (Pharmacodynamics) and also be capable of reaching that target (Pharmacokinetics). G. Patrick Medicinal chemistry Medicinal chemistry concerns the discovery, development, identification, and the interpretation of the mode of action of biologically active compounds at the molecular level. IUPAC It provides thus, the chemical basis for the interdisciplinary field of therapeutics Medicinal chemistry involves the isolation, characterization, and synthesis of compounds that can be used in medicine for the prevention, treatment, and cure of disease. Burger BASED ON THE HOPE OF FINDING BIOCHEMICAL RATIONALES FOR DRUG DISCOVERY. BASED ON THE HOPE OF FINDING BIOCHEMICAL RATIONALES FOR DRUG DISCOVERY. Finding the biochemical pathway through which drugs exert their beneficial effects has become a dominating activity of medicinal chemist It is also called therapeutic chemistry, pharmaceutical chemistry, and pharmaco- chemistry ? ?A Medicinal Chemist is skilled in the field of organic synthesis, molecular modeling and drug design. And should have a basic knowledge of relevant subjects such as biochemistry and Pharmacology. Medicinal Chemist Pharmaceutical chemistry: concerned primarily with modifications of structures having known physio