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Diabetic Neuropathy Beverly J. Mathis, D.O. November 2007 Definition Complex syndrome of neurological abnormalities caused by the metabolic and vascular complications of diabetes. Class I Subclinical Neuropathy Abnormal electrodiagnostic tests Decreased nerve conduction velocity Decreased amplitude of evoked muscle or nerve action potential Abnormal quantitative sensory testing Vibratory/ warming/cooling Abnormal autonomic function tests Sinus arrhythmia (beat-to-beat heart rate variation) Inc