第二节 尿液的生成过程.pdf

glomerular filtration membrane Glomerular Filtration Membrane ccapillary endothelium: Endothelial capillary pores are large fenestrae. Negative charge. Pores are small enough to prevent RBCs, platelets, and WBCs from passing through the pores. FFiltrate must pass through the basement membrane: Thin glycoprotein layer. Strong negative charges. Can filter water and small solutes. Podocytes: Foot pedicels form small filtration slits. Passageway through which filtered molecules must pass. Filterability of substances Substance Molecular Weight Filterability Water 18 1.0 Sodium 23 1.0 Glucose 180 1.0 Inulin 5500 1.0 Myoglobin 17000 0.75 Albumin 69000 0.005 Glomerular Ultrafiltrate Fluid that enters glomerular capsule is called ultrafiltrate. Composition: Water some solutes from blood - electrolytes, glucose, amino acids, nitrogenous wastes, vitamins no protein(Plasma proteins are excluded by size and charge) no RBC’s effective filtration p