医学细胞生物学课件：2 Cell Membrane.pptVIP

糖萼与微绒毛 Cell membrane disease 1.1 Hereditary spherocytosis 1.2 cystic fibrosis 1.3 LDL receptor deficiency disease Hereditary spherocytosis Hereditary spherocytosis Hereditary spherocytosis Hereditary spherocytosis cystic fibrosis Protein Misfolding Diseases (also known as Protein Conformational Diseases) Disorders arising from the failure of a specific peptide or protein to adopt, or remain in, its native structure Diseases in which an impairment in the folding efficiency of a given protein results in a reduction of native folded protein. ribosome nascent chain of CFTR ribosome folded, functional CFTR on the cell membrane end of translation, folding on the ER membrane, translocation to the cell membrane nascent chain of CFTR ribosome nascent chain of CFTR ribosome nascent chain of CFTR misfolded CFTR ribosome nascent chain of CFTR misfolded CFTR no folded CFTR on the cell membrane cystic fibrosis LDL receptor deficiency disease Thank you for your attention! Figure. The three-dimensional structure of the photosynthetic reaction center of the bacterium Rhodopseudomonas viridis. The structure was determined by x-ray diffraction analysis of crystals of this transmembrane protein complex. The complex consists of four subunits, L, M, H, and a cytochrome. The L and M subunits form the core of the reaction center, and each contains five a helices that span the lipid bilayer. The locations of the various electron carrier coenzymes are shown in black. (Adapted from a drawing by J. Richardson based on data from J. Deisenhofer et al., Nature 318:618-624) * * * * * * * * * * Any Questions?? Characteristics of cell membrane Membranes are fluidity Fluidity of membrane lipid. It give membranes the ability to fuse, form networks, and separate charge; Motility of membrane protein. Phospholipids can rapidly diffuse along the plane of the membrane Nearest neighbor replacement rate is ~10-8/sec Flip-flop is a rare process – leafle