《基础医学各论II》课件：内分泌系统药理-甲状腺和抗甲状腺药物.pdfVIP

Part 2 Part 2 Thyroid hormones and Thyroid hormones and antithyroid drugs antithyroid drugs A. Thyroid hormones A. Thyroid hormones Metabolism of thyroid hormones Metabolism of thyroid hormones 1. Uptake of iodide 1. Uptake of iodide 2. Activation of iodide (peroxidase), and iodination 2. Activation of iodide (peroxidase), and iodination and coupling of tyrosine and coupling of tyrosine 3. Formation of thyroxine (T ) and triiodothyronine 3. Formation of thyroxine (T ) and triiodothyronine 4 4 (T )from iodotyrosine (T3)from iodotyrosine 3 4. Secretion of thyroid hormones (proteolytic 4. Secretion of thyroid hormones (proteolytic enzymes) enzymes) 5. Regulation by thyroid stimulating hormone 5. Regulation by thyroid stimulating hormone (TSH), T , T (TSH), T4, T3 4 3 Metabolism of thyroid hormones Metabolism of thyroid hormones Metabolism of thyroid hormones Metabolism of thyroid hormones Formation of Formation of thyroxine (T ) and thyroxine (T4) and 4 triiodothyronine (T ) triiodothyronine (T3) 3 from iodotyrosine from iodotyrosine Formation of thyroxine (T ) and triiodothyronine (T ) from Formation of thyroxine (T ) and triiodothyronine (T ) from 4 3 4 3 iodotyrosine iodotyrosine Secretion of thyroid Secretion of thyroid hormones ( lysosomal hormones ( lysosomal proteolytic enzymes ) proteolytic enzymes ) Regulation of the Regulation of the secretion of thyroid secretion of thyroid hormones (feedback hormones (feedback inhibition) inhibition) Pharmacology of th