武汉大学分子生物考研复习.pptVIP

Welcome each of You to My Molecular Biology Class 博字 Wuhan University  Molecular Biology of the Gene 5/E --Watson et al. ( 2004) Part I: Chemistry and Genetics Part ll: Maintenance of the Genome Part I: Expression of the Genome Part IV: Regulation Part v: methods 3/29/05 博字 Wuhan University  Part ll: Maintenance of the Genome Dedicated to the structure of DNA and the processes that propagate, maintain and alter it from one cell generation to the next Wuhan University  Ch 6: The structures of dna and rna Ch 7: Chromosomes, chromatins and the nucleosome Ch 8: The replication of DNA Ch 9: The mutability and repair of NA ch 10: Homologous recombination at the molecular level Ch 11: Site-specific recombination and transposition of dNa 3/29/05  Different changes of DNA sequences Listen to the nature Mutation is bad and naturally repaired thus it could not be responsible for biodiversity. Recombination is good and naturally promoted; it is responsible for diversity inside of species. Transposition is different from mutation and recombination because producing mechanism is different; 2)no mechanism to correct it;(3) existing in nature in a well-controlled manner(10-5). Not repaired but controlled  Molecular Biology Course CHAPTER 10 Homologous recombination at the molecular level @肃博来字 Wuhan University  All DNA is recombinant dna Genetic exchange works constantly to blend and rearrange chromosomes, most obviously during meiosis, when homologous chromosomes pair prior to the first nuclear division a During this pairing, genetic exchange between the chromosomes occurs. This exchange, classically termed crossing over is one of the results of homologous recombination.  OUTLINE 1. Models for Homologous Recombination(two models)xk 2. Homologous Recombination Protein Machines (RecBCD pathway*xK 3. Homologous Recombination in Eukaryotes(meiosis recombination, proteins) 4. Mating-Type Switching(a gene conv