动力学拆分区分构象稳定性（Hoffmann测试）.pdfVIP

Determination of Configurational Stability
 Based on Kinetic Resolution
 (Hoffmann Test)  A. Basu.; S.Thayumanavan. Angew. Chem. Int. Ed. 2002 , 41 , 716-738. R. Hirsch.; R. W. Hoffmann. Chem. Ber. 1992, 125, 975-982. P. OBrien.; H. R. Powell.; P. R. Raithby.; S. Warren. J. Chem. Soc., Perkin Trans. 1, 1997, 1031-1039. 2008.7.19��� (1) formation (2) epimerization (3) substitution H Li H E retention X * Y X * Y 2 3 H H epimerization inversion X Y 1 Li H retention E H X * Y X * Y ent-2 ent-3 A. Basu.; S.Thayumanavan. Angew. Chem. Int. Ed. 2002 , 41 , 716-738. E R3 O kR OR SR PR O O * RO Ti Ti E kR = kS O E O O R2 R1 kS O SS PS iPrO O tBu E=CO2iPr (R) TMS n-C H * 5 11 (±)-