胺的动力学拆分.pdfVIP

Me Me O Me acylating reagent NH2 N R + NH2 H 1899 Marckwald McKenzie carboxylic acid O O OH O HO HO OH HO OH O + (S)-mandelic acid amine O Me Me O chiral reagent (0.25 eq) ! N NH2 N CH3 rt H O H N 48%ee s = 3 O 25% conv.