外科学-总论英文课件：Transplantation.ppt

Liver Transplantation Pediatric liver transplantation Welcome to join us！ * Heart transplantation Indications: end-stage heart disease Spontaneous ischemic heart disease, Congenital heart disease, Valvulopathy, Viral myocarditis, etc Features Operation is relatively simple but costly, the post-operation management is more complicated, organ preservation condition and ischemia time demanding is strict, and cardiac biopsy frequently may overwhelmed the patient. Organ Transplantation Pancreas transplantation Indication Severe diabetes with end-stage renal disease Status of post total pancreatectomy Features The majority of pancreas transplantation are simultaneous pancreas-kidney transplantation and has a high rate of postoperative complication. But the prognosis is very good. Organ Transplantation Intestinal transplantation Indication: Short bowel syndrome caused by massive small bowel resection The prognosis is poor due to the sever rejection and graft failure. Lung transplantation Indication: end-stage lung disease The prognosis is also poor due to the severe infection and obstructive bronchitis. Organ Transplantation Basic Concepts History Transplantation Immunity Organ Procurement Organ Transplantation Liver Transplantation Transplantation Indications Liver Transplantation Benign end-stage liver disease Posthepatitis cirrhosis Alcoholic cirrhosis Primary biliary cirrhosis(PBC) Primary sclerosing cholangitis(PSC) Congenital metabolic liver disease (Wilson’s disease, α-1 antitrypsin deficiency, Glycogen deposition disease, etc） Fulminant hepatic failure Budd-Chiari syndrome Polycystic liver Malignant end-stage liver disease Liver cancer with decompensated cirrhosis Liver cancer located in speical region Liver Transplantation Contraindications Uncontrolled metastatic cancer outside liver Uncontrolled infections(bacteria, fungus and virus) Active drug or alcohol abuse Serious heart, pulmonary or other disease Infection with HIV Uncont