临床基因组学：临床基因组检验技术概论.ppt

1882:Flemming first reported microscopic structure of chromosomes the above picture was his sketch of what he saw under microscope 1921: Painter reported human cells have 48 ( counted prisoned male sperm cell 24 chromosomes, therefore deduced 48 for somatic cells). 48 had never been challenged until 1956 * 1882:Flemming first reported microscopic structure of chromosomes the above picture was his sketch of what he saw under microscope 1921: Painter reported human cells have 48 ( counted prisoned male sperm cell 24 chromosomes, therefore deduced 48 for somatic cells). 48 had never been challenged until 1956 * 1882:Flemming first reported microscopic structure of chromosomes the above picture was his sketch of what he saw under microscope 1921: Painter reported human cells have 48 ( counted prisoned male sperm cell 24 chromosomes, therefore deduced 48 for somatic cells). 48 had never been challenged until 1956 1956: Tjio corrected from 48—46条 1959年： 21T 被发现与down syndrome 的关系，也是人类第一个被发现的染色体异常导致的疾病 1962年： 费城会议中报道了白血病有一个marker chromosome 1968-1970’ 显带技术发展， 1972： 确认bcr-ABL 易位 1978： 高分辨染色体显带技术发展，~500 * 1882:Flemming first reported microscopic structure of chromosomes the above picture was his sketch of what he saw under microscope 1921: Painter reported human cells have 48 ( counted prisoned male sperm cell 24 chromosomes, therefore deduced 48 for somatic cells). 48 had never been challenged until 1956 1956: Tjio corrected from 48—46条 1959年： 21T 被发现与down syndrome 的关系，也是人类第一个被发现的染色体异常导致的疾病 1962年： 费城会议中报道了白血病有一个marker chromosome 1968-1970’ 显带技术发展， 1972： 确认bcr-ABL 易位 1978： 高分辨染色体显带技术发展，~500 * 1882:Flemming first reported microscopic structure of chromosomes the above picture was his sketch of what he saw under microscope 1921: Painter reported human cells have 48 ( counted prisoned male sperm cell 24 chromosomes, therefore deduced 48 for somatic cells). 48 had never been challenged until 1956 1956: Tjio corrected from 48—46条 1959年： 21T 被发现与down syndrome 的关系，也是人类第一个被发现的染