生物分离工程-双语版-8资料讲解.ppt

生物分离工程-双语版-8;Downstream processing equipment;Bring a drug to market ;;Development time of biopharmaceuticals from FDA;;;Biotechnological product ready for market;Process development consideraton;Downstream processing costs play a major role; ; Centrifugation 1 In biotechnology, centrifugation is effectively used to separate products that exhibit very small differences in ] specific gravity. 2 Compactly designed centrifuges have efficient economies of scale.;1.Capital costs The capital costs of centrifuges runs from $50,000 to $500,000 depending on the size and configuration selected. Often the cost is strongly dependent on the specification required of the centrifuges.;4.Nontangible（不确定性的） costs Often neglected when purchasing a centrifuge system. e.g. compact centrifuge may save or make available floor space on the shop floor microbial cells have a disposal cost associated with them, the drier the cake is, the less is the disposal cost ;;In designing a process, the objectives should be clearly stated;Emphasized ;Scale-up should be attempted only when: a suitable processing strategy in accord with the product to be purified has been developed The process has been optimized on the laboratory scale;The modifications: Process optimization needs to be carries out continuously to improve the economics of the modified process.;Three ways to change a chromatographic column Maintaining a constant column area extremely long columns Increase column diameter while holding the bed height constant:;Perfusion chromatography;Cost function ;Cost in running separations;Conclusions;此课件下载可自行编辑修改，仅供参考！感谢您的支持，我们努力做得更好！谢谢