抗高血压药-课件英文版.ppt

 Antihypertensive drugs;hypertension; complications;Antihypertensive drugs;Blood pressure;main centre;Second, humoral regulation: renin – angiotensin aldosterone system;Classification;Diuretic;Hydrochlorothiazide;disadvantages :;;Clinical application;Effect of diuresis medicine of compound preparations with other drugs;Calcium antagonist medicine;Nifedipine;Clinical application;Nitrendipine;Lacidipine;Amlodipine;Adrenaline receptor blockers;Mechanism of action;Clinical application;atenolol;labetalol;carvedilol）; Renin angiotensin system depressants;【 Antihypertensive mechanism 】 1.AngII Generate and function 。 － Arteriovenous diastolic → Peripheral resistance ↓→ Blood pressure ↓； － Block the release of aldosterone water sodium retention ； 2. Inhibition of slow excitation peptide degradation ↓ Slow excitation peptide concentrations in the blood ↑: produce NO、PG2 Etc. →血管扩张→血压↓ ;【 Function characteristics 】 1 orally active, work fast, antihypertensive effect of medium strong; 2 without reflective heart rate, long-term use without resistance, not easy to cause the electrolyte disorders; Three pairs of renal hypertensive effect is good, can treat refractory heart failure ;【 application 】 Each period high blood pressure. Important first-line drugs. Especially suitable for complicated with diabetes and insulin resistance and left ventricular hypertrophy, heart failure, acute myocardial infarction patients with high blood pressure ;Angiotensin Ⅱ receptor blockers ARB AT1 receptor: vascular smooth muscle, cardiac muscle, brain, kidney and secretion of aldosterone Adrenal zona cells - has regulating effect to the stability of the cardiovascular function. losartan 【 Antihypertensive mechanism 】 Selective blocking AT1 receptor: blocking angiotensin Ⅱ mediated blood vessels Shrinkage, aldosterone release and promote vascular smooth muscle proliferation and effect → Peripheral resistance ↓ Promoting uric acid excre