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* * * T-淋巴细胞的增殖降低了在Sepsis;单核细胞的吞噬能力提高了在Sepsis; * HCO治疗恢复了淋巴细胞的增殖能力 * HCO治疗降低了单核细胞的吞噬能力 * HCO治疗的临床益处 * 去甲肾上腺素的用量明显下降 * 急性生理评分(SAPS)的改进 * * * * 抗凝血酶;C反应蛋白 * * * Stable albumin plasma levels during treatment N=24 pts CVVH/ CVVHD Am J Kidney Dis. 2004, 43:444-53. Coagulation Status During High Cut-Off Hemofiltration Intensive Care Med 2003;29:1989-95 N=16 pts CVVH ● Days on Norephrinine (10,0 ±9 vs 11,3 ±9) ● Days on Ventilation (13,9 ±11 vs 16,1 ±11) ● Need for RRT (9,1 ±8 vs 9,5 ±8) HCO versus standard high flux Recent HPHF Studies in Sepsis High-Flux HCO Honore PM et al. 10th Congress of WFSICCM.Florence 2009 N= 81 pts CVVHD HICOSS (High Cut-Off Sepsis Study) Multicenter study with HCO in septic AKI Reduction of catecholamine requirements by High Cut off-CVVHD : clinical improvements and Safety (albumin levels), SOFA ● Days 28 mortality (31 vs 33%) ● both groups lower than predicted by APACHE score ● Days in ICU (19±12 vs 19±11) HCO vs standard high flux Recent HPHF Studies in Sepsis: HCO High-Flux Honore PM et al. 10th Congress of WFSICCM.Florence 2009 N= 81 pts CVVHD HICOSS (High Cut-Off Sepsis Study) Multicenter study with HCO in septic AKI Reduction of catecholamine requirements by High Cut off-CVVHD : clinical improvements and Safety (albumin levels), SOFA HCO versus standard high flux Safety: Stable plasma albumin levels with HCO compared to standard high flux -CVVHD N= 81 pts CVVHD Recent HPHF Studies in Sepsis: Honore PM et al. 10th Congress of WFSICCM.Florence 2009 HICOSS (High Cut-Off Sepsis Study) Multicenter study with HCO in septic AKI Reduction of catecholamine requirements by High Cut off-CVVHD : clinical improvements and Safety (albumin levels), SOFA HCO versus standard high flux Recent HPHF Studies in Sepsis: Synergy with HVHF ? CVVH + HPHF= 1l/h = 16.6 ml/kg/h HVHF+HPHF = 6 l/h = 80 ml/kg/h Uchino el al , Int Care Med 2002; 28: 651-655 百特HF系列滤器特点1 百特HF系列是高截留分子量HCO ,聚砜膜血滤器的一种,合理的筛漏系数,截流分子量为65KD ?膜生
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