新生儿脐炎92例脐部分泌物病原菌及耐药性分析.docxVIP

新生儿脐炎 92 例脐部分泌物病原菌及耐药性分析 【摘要】 目的 :了解新生儿脐炎病原菌分布及其耐药性 , 为本病提供预防及治疗参考。方法 :调查我院 2007 年 1 月― 2011  年  9 月收治的有完整资料新生儿脐炎  114 例,  对脐部分 泌物所分离到的  92 株致病菌的种类及药敏状况进行分析。 结果 :114  例中检出  92 株致病菌，检出率  80.7% (92/114) ，革 兰氏阳性菌 60 株，占 65.2% (60/92) ，金黄色葡萄球菌 39 株，占 42.4% （39/92) ，凝固酶阴性葡萄球菌 21 株，占 22.8% （21/92) ，革兰氏阴性菌 31 株 , 占 33.7% (31/92), 大肠埃希菌 9 株，占 9.8%(9/92) ，肺炎克雷伯菌 7 株，占 7.6%（ 7/92），其它革兰氏阴性菌 15 株，占 16.3%（ 15/92），真菌 1 株，占 1.1%(1/92) 。耐甲氧西林葡萄球菌（ MRS ）65.0 %(39/60) ，产超广谱 β -内酰胺酶 (ESBLs) 大肠埃希菌和肺炎克雷伯菌分别 为 55.6% (5/9) 、 57.1% (4/7) 。均具有多重耐药性。结论 : 新 生儿脐炎的病原菌主要为金黄色葡萄球菌、表皮葡萄球菌、 大肠埃希菌、 肺炎克雷伯菌等， 耐甲氧西林葡萄球菌 （ MRS ） 及产超广谱 β -内酰胺酶 (ESBLs) 株增多 , 加强新生儿脐部护 理, 减少新生儿脐炎仍十分必要。 【关键词】脐炎 ;病原菌 ;耐药谱 Study on 92 pathogens and drug-resistance of Newborn omphalitisSHEN An-ying. Quan Cai-qiDepartment of Pediatrics, Jinshan Branchofthe Sixth People ’ s Hospitai of Shanghai Jiaotong University, Shanghai 201500, Zang Jan-Hua the Sixth People ’ s Hospitai of Shanghai Jiaotong University 200233China Abstract 】: OBJECTIVETo investigate the distribution of pathogens of neonate navel infection and their drug sensitivity to antibiotics, and to provide basis to choose rational antibiotics for clinical treatment of neonatalomphalitis. METHODSBacteria culture and antibiotic sensitivity test were undertaken for infected navel secretion of 114 newborn cases selected fromJan2007 to Sep 2011 were conducted, the category and antibiotic sensitivity of the obtained 92 pathogens were analyzed. RESULTSAmong the 114 cases, 92 pathogens were isolated. positive strains 80.7%(92/114). The main pathogens were Gram-positive cocci accounted for 65.2%(60/92), the most of which wereS.aureus42.4% （ 39/92)，coapulase-negative staphylococcus22.8%(21/92).The Gram-negative bacillipathogens took up 33.7%(31/92), among which Escherichia coli accounted for (9.8%)(9/92). K. Penumoniae accounted for (7.6%)(7/92) , other Gram-negative bacillipathogens16.3% （ 15/92） and fungi 1.1%(1/92). MRS occupied 65.0%(39/60),E. coli and K. Penumoniae