蛇床子素和葛根素对福美双诱导的肉鸡胫骨发育不良的治疗作用及分子机制研究.pdfVIP

Therapeutic efficacy and molecular mechanism study of osthole and puerarin against thiram-induced tibial dyschondroplasia in broiler chickens CONTENTS CONTENTSI LIST OF FIGURESIV LIST OF TABLESV 摘要i ABSTRACTiii LIST OF ABBREVIATIONSv CHAPTER 11 General Introduction1 1.1. Endochondral bone formation and ossification1 1.2. Epiphyseal growth plate2 1.2.1. Reserve zone3 1.2.2. Proliferative zone3 1.2.3. Transition zone .3 1.2.4. Prehypertrophic zone3 1.2.5. Hypertrophic zone3 1.3. Avian growth plate4 1.4. Tibial dyschondroplasia (TD)5 1.5. Tetramethylthiuram disulfide (Thiram)7 1.6. TD and gene expression8 1.6.1. Role of Bone morphogenetic protein-2 (BMP-2) in TD9 1.6.2. Role of Runt-related transcription factor-2 (RUNX-2) in TD9 1.6.3. Role of Hypoxia Inducible Factor-1α (HIF-1α) in TD10 1.6.4. Role of Tissue inhibitor of metalloproteinase-3 (TIMP-3) in TD10 1.6.5. Role of B-cell lymphoma-2 (BCL-2) in TD11 1.7. Prevention and Treatment of TD11 1.8. Traditional Chinese Medicines12 1.8.1. Osthole13 1.8.2. Puerarin13 1.9. Conclusion and Hypothesis14 CHAPTER 216 I Huazhong Agricultural University, PhD dissertation Osthole: A Coumarin Derivative Assuage Thiram-Induced Tibial Dyschondroplasia by Regulating BMP-2 and RUNX-2 Expressions in Chickens16 2.1. Introduction16 2.2. Objectives17 2.3. Materials an