0.01%阿托品联合中药离子导入控制儿童中低度近视进展的临床观察.docxVIP

0.01%阿托品联合中药离子导入控制儿童中低度近视进展的临床观察 查桂平 汪卓琼 [摘要] 目的 比較单独使用阿托品与阿托品联合中药离子导入控制儿童中低度近视进展的疗效。 方法 收集20XX年4月～20XX年6月在我院眼科就诊的6～12岁中低度近视儿童115例，随机分为3组，分别接受0.01%阿托品联合中药离子导入、0.05%阿托品、0.01%阿托品治疗12个月。观察治疗后等效球镜、眼轴、视力、瞳孔直径、调节近点的变化。 结果 治疗12个月后，0.01%阿托品联合中药离子导入组、0.05%阿托品组、单独使用0.01%阿托品组等效球镜分别为（-2.38±0.52）D、（-2.43±0.45）D、（-2.52±0.29）D，眼轴长度分别为（24.33±0.28）mm、（24.36±0.37）mm、（24.51±0.15）mm，三组等效球镜度数与眼轴长度比较，差异均有统计学意义（F=4.969，P=0.011;F=3.315，P=0.039）。0.05%阿托品组明室瞳孔直径（5.75±0.83）mm比0.01%阿托品联合中药离子导入组（5.20±0.61）mm、0.01%阿托品组（5.35±0.91）mm增加明显（P0.001）。调节近点0.05%阿托品组（10.11±0.42）cm比0.01%阿托品联合中药离子导入组（8.74±0.72）cm、0.01%阿托品组（8.55±0.83）cm增加明显（P0.001）。结论 中药离子导入加强了0.01%阿托品控制近视进展作用，其作用效果相当于0.05%阿托品。同时，需要进一步观察等效球镜及眼轴的变化情况。 [关键词] 0.01%阿托品;中药离子导入;中低度近视;儿童 [中图分类号] R778.11 [文献标识码] B [文章编号] 1673-9701（2020）09-0097-04 [Abstract] Objective To compare the effect of atropine alone and atropine combined with traditional Chinese medicine iontophoresis on the development of middle and low myopia in children. Methods 115 middle and low myopia children aged 6 to 12 years treated in our hospital from April 20XX to June 20XX were selected. They were randomly divided into three groups. And the three groups were given 0.01% atropine combined with traditional Chinese medicine iontophoresis， 0.05% atropine and 0.01% atropine for 12 months respectively. After treatment， the changes of equivalent spherical lens， ocular axis， visual acuity， pupil diameter and accommodation of near point were observed. Results After 12 months of treatment， the spherical equivalent in 0.01% atropine combined with traditional Chinese medicine iontophoresis group， 0.05% atropine group and 0.01% atropine group were （-2.38±0.52） D， （-2.43±0.45） D， （-2.52±0.29） D respectively， and the length of the ocular axis was （24.33±0.28） mm， （24.36±0.37） mm， （24.51±0.15） mm respectively. The differences in the equivalent spherical lens and the length of the ocular axis between the three groups were statistically significant（F=4.969， P=0.