临床病理学1 ats前沿.pdf

Fibrosis (IPF(IPF、fibroblast/epithelium)fibroblast/epithelium) ATS KEYNOTE SERIES Epithelial Mesenchymal Transition: Is It Still Relevant to Pulmonary Fibrosis? EMT that ludes epithelial–mesenchymal interactions and responses. Oral Poster Presentations and Posters A2378 - Using Pulmonary Surfactant as Pirfenidone Vehicle to Target Lung Epithelium in Bleomycin-Induced Lung Fibrosis A23789- Adenovirus-Mediated Overexpression of Lactate Dehydrogenase Induces Pulmonary Fibrosis. We hypothesize that lactate is a pro-fibrotic mediator, and that overexpression of LDHA and downstream lactate production is sufficient to induce pulmonary fibrosis in vivo. A2392 - Telomere Dysfunction in Alveolar Epithelial Cells Causes Pulmonary Fibrosis. A2413 - Glucose Uptake in TGFβ-Induced Fibroblast Differentiation. reased glucose uptake, upregulated glucose transporters and reased glucose metabolism. This supports the notion of an reased glycolytic demand during this highly synthetic process. A2416 - Role of Epithelial to Mesenchymal Transition (EMT) in Idiopathic Pulmonary Fibrosis. BPD, Bronchi Pulmonary Dysphasia ((支气管肺发育不良支气管肺发育不良)) Orchestration of risk factors and pathophysiologic variables with anticipated treatment potential in the development of BPD Niedermaier and Hilgendorff., Molecular and Cellular Pediatrics (2015) Animal models of BPD •Mouse •7–14 days hyperoxia •Baboons •IL-1β transgenic mice •Transgenic IFN-γ overexpressing mice •Lambs •TGF-β transgenic mice A3849 - Extracellular Adenosine in Hyperoxic Lung Injury Regulates Inflammation in a Newborn Murine Model of Bron