培美曲塞联合草酸铂一线治疗老年或功能状态评分差的晚期非小细胞肺癌的临床研究.docVIP

培美曲塞联合草酸钳一线治疗老年或功能状态评分差的晚期非小细胞肺癌的临 床研究 发表时间:2010-02-01发表者:$0 (访问人次:126) 南京市胸科医院呼吸二科210029 【摘耍】目的：评价培美曲塞联合草酸钳治疗老年( 70岁)或功能状态评分羌的晚期非小细胞肺癌(NSCLC)的有效性和安全性。方法：研究对象为2007年7月?2009年3月收治的未接受过一线化疗的老年或功能状态评分差【IIB /IV期的非小细胞肺癌患者，采用培美曲塞联合草酸钳方案，每3周为1个周期重复。每2个周期评估疗效，直至疾病进展；观察近期疗效和不良反应，进行随访。结果:32例患者中CR 0例(0%), PR 5例(15.6 %), SD 7例(21.9%),PD 12 例(62. 5%)，总有效率(C R + P R )为 15. 6 % ,疾病控制率(CR+PR+SD)为 37. 5%。全纽?病例随访2?20个月，3例至2009年3月仍然存活，随访率100亂总休平均生存期7. 5个月(2?20个月)，中位生存期8个月，1年生存率21. 9%o主耍的毒副反应时血红蛋白减少、中性粒细胞减少、中性粒细胞减少性发热、血小板减少、脱发、恶心呕吐、腹泻等，发生率分别为 25%、18.8%、15.6%、18.8$、25%、21.8%、18.8%0 结 论：培美曲塞联合草酸钳方案治疗或功能状态评分差的晚期非小细胞肺癌患者的疗效较好，不良反应较轻，患者的耐受性好。 【关键词】晚期非小细胞肺癌；老年患者；功能状态评分差的患者；培美曲塞;草酸钳 【中图分类号】K734. 2【文献标识码】【文章编号】1673-5269 (2009) 23-1889-03 Clinical Effect of Femetrexed Combined with oxaliplatin as Front-Line Treatment of Advanced Non-Small Cell Lung Cancer in Elder ly Patients or Patients Ineligib le Li Ticin . No.2 Department of Respiratory Medicine, Nanjing Chest HopitaL Jiangsu, 210029,China Corresponding author： Li Tian, E-mail： lltl2003@y“hoa com? cn 【Abstract】： Objective: To observe the clinical efficacy and adverse effect o f pemetrexed combined with oxaliplatin to treat elderly patients or petients ine ligible with late-stage non-small cell lung cancer Methods: Elderly p“tients or patients ineligible with advanced NSCLC ( IIIB /IV stage) were recruited in this study. They had recurrence after receiving at leest one or two regimens of plat inum-based chemotherapy from July 2007 to March 2009. Pemetrexed Combined with o xtiliplatin was given every 3 weeks as a cycle until disease progression? The cli nical outcome and adverse reaction were observed? Patients were followed up. Res ults: Among the 32 patients, 0 p“tients got complete response(0%), 5 patients go t partial response (15.6% ) , 7 stable disease (21.9% ) , and 12 progressive dis ease (62.5% )? The total response rete ( C R + P R ) was 15. 6% and disease contr ol rate including tumor response and stable disease was 37. 5%