2型糖尿病患者微血管病变同MPV、hs-CRP、CD62P及HbAlc指标的关系.docxVIP

2型糖尿病患者微血管病变同MPV、hs-CRP、CD62P及HbAlc指标的关系 Relationship between Microvascular Disease and MPV， hs-CRP， CD62P and HbAlc in Type 2 Diabetes LIU Yuan-zhi， ZHANG Wei， PAN Yan-hui， LI Wei， LI Wei-wei， LIU Fu-jia Department of Endocrinology， Qiqihar First Hospital， Qiqihar， Heilongjiang Province， ***** China [Abstract] Objective This study mainly analyzes the relationship between microangiopathy and average platelet volume （MPV）， high-sensitivity C-reactive protein （hs-CRP）， platelet alpha protein （CD62P） and glycosylated hemoglobin （HbAlc） indexes in patients with type 2 diabetes. Methods A total of 94 patients with type 2 diabetes who were hospitalized in the hospital from April 2017 to January 2019 were selected as the observation group. According to the presence or absence of microvascular disease， the patients were divided into a disease group of 43 cases and a disease-free group of 51 cases. In the same period， 94 cases without type 2 diabetes physical examination were selected as the control group. Using different detection instruments to record MPV， hs-CRP， CD62P and HbAlc index of the enrolled subjects， and statistical analysis was performed. Results The MPV， hs-CRP， CD62P and HbAlc indexes of the observation group were higher than the control group， the difference was statistically significant（P0.05）; the MPV， hs-CRP， CD62P and HbAlc indexes of the disease group were higher than that of the non-lesion group， the difference was statistically significant （P0.05）; MPV in the observation group was positively correlated with CD62P， HbA1c and hs-CRP indicators（P0.05）. Conclusion The relationship between microangiopathy and MPV， hs-CRP， CD62P and HbAlc indexes in type 2 diabetes patients is closely related to early detection and treatment. [Key words] Type 2 diabetes; MPV; hs-CRP; CD62P; HbAlc 近年來，由于人们生活水平日益提高，糖尿病的发病率也在逐年升高。糖尿病作为一种严重的慢性病，其并发症严重影响着患者的生活。其中糖尿病并发的血管性病变更是致残和致死的重要原因之一。有关研究表明，糖尿病患者并发微血管病变常伴随着血小板异常，并可伴随一系列体内炎性反应，从而引起体内激素及各项指标的波动。通过查阅文献，在