生物化学资料：22-nucleotide metabolism-(李)-15年-上.pptVIP

Structures of pyrimidine antimetabolites 胸腺嘧啶(T) 5-氟尿嘧啶(5-FU) FdUMP FUTP 5 5 Pyrimidine antimetabolites 5-fluorouracil FdUMP Inhibitions thymidylate synthase N5, N10-methylene FH4 FH2 FH2 reductase FH4 NADP+ NADPH+H+ dUMP dTMP methotrexate _ _ F. Salvage of pyrimidines Pyrimidines + PRPP Pyrimidine nucleotide + PPi Pyrimidine phosphoribosyltransferase Uridine + ATP Uridine kinase UMP +ADP Deoxythymidine + ATP Thymidine kinase dTMP +ADP （U、T、O） Regulations of pyrimidine synthesis ATP + CO2+ glutamine carbamoyl phosphate UMP carbamoyl aspartate UTP CTP glutamate ATP + ribose 5-phosphate PRPP CPS-Ⅱ aspartate transcarbamoylase PRPP synthetase mammals bacteria purine nucleotide pyrimidine nucleotide - - - - 1、Degradation of pyrimidine nucleotides G. Degradation of pyrimidine nucleotides H2O Pi Pi Nucleoside phosphorylase Pyrimidine nucleotides Pyrimidine nucleosides Pyrimidines Nucleotidase Ribose 1-phosphate (Phosphorolysis reaction) cytosine uracil dihydrouracil thymine dihydrothymine β-ureidoisobutyrate β-aminoisobutyrate β-alanine β-ureidopropionate Dihydrouracil dehydrogenase Dihydropyrimidinase β-ureidopropionase cytosine deaminase Uracil dehydrogenase Dihydropyrimidinase 2. Degradation of pyrimidines * 2010年5月24日，第七节到此 * 顾三-p236 * Cyclic nucleotides 环核苷酸 cAMP cAMP cGMP III. Synthesis of purine nucleotide The pathways of nucleotide synthesis include: 1. de novo pathway (从头合成途径 ) 2. salvage pathway (补救合成途径) the de novo pathway of nucleotide synthesis a pathway through which nucleotides are synthesized by using simple molecules, such as ribose 5-phosphate, amino acids, one carbon units and CO2. de novo synthesis Location: liver, small intestine, thymus (note: but not brain and bone marrow) R-5-P ATP AMP PRPP synthetase PP-1-R-5-P （PRPP ） Gln, Gly, one carbon unit, CO2, and Asp are added. IMP AMP GMP H2N-1-R-5′-P （PRA） Gln Glu Gln:PRPP amidotransferase Pathway in brief A. Synthe