白血病分子生物学知识小结.pptx

白血病分子生物学知识小结零微一未两部分三四五，粒和单六红七巨是为髓一小二大三原淋费城染色体比正常染色体小，与CML有关Burkitt lymphomaAll types of Burkitt lymphoma are characterized by disregulation of the /wiki/C-mycc-/wiki/C-mycmyc gene by one of three chromosomal translocations. This gene is found at /wiki/Chromosome_88q24.The most common variant is t(8;14)(q24;q32), which accounts for about 85%/wiki/Burkitts_lymphoma#cite_note-Hoffman-9[9] of cases. This involves /wiki/C-mycc-/wiki/C-mycmyc and /wiki/IGH@IGH@. A variant of this, a three-way translocation, t(8;14;18), has also been identified./wiki/Burkitts_lymphoma#cite_note-pmi10[10]A rare variant is at t(2;8)(p12;q24)./wiki/Burkitts_lymphoma#cite_note-pmi11[11] This involves /wiki/IGK@IGK@ and c-myc.Another rare variant is t(8;22)(q24;q11)./wiki/Burkitts_lymphoma#cite_note-pmi11[11] This involves /wiki/IGL@IGL@ and c-myc.Combined, the two less-common translocations, t(2;8)(p12;q24) and t(8;22)(q24;q11), account for the remaining 15% of cases not due to the t(8;14)(q24;q32) translocation.套细胞淋巴瘤套细胞淋巴瘤占全部非霍奇金淋巴瘤(NHL)的6%。这类淋巴瘤以前归在其他亚型中，只有最近十余年才被认识到是一类独立疾病。认识到这些淋巴瘤有特征性染色体移位t（11；14）即第14号染色体上免疫球蛋白重链基因和第11号染色体上Bcl-1基因之间移位，有规律地过度表达Bcl-1蛋白，最具特点的是过度表达Cyclin D1，故肯定了该类淋巴瘤的存在。真性红细胞增多症PV – JAK2基因突变V617F与PV相关性很强。骨髓增生异常综合症的11q缺失突变预后极好。CHOP方案治疗弥漫性大B细胞淋巴瘤DLBCL/pubmedeukemia. 2002 Feb;16(2):268-75.Point mutations of the BCL-6 gene: clinical and prognostic correlation in B-diffuse large cell lymphoma./pubmed/?term=Vitolo%20U%5bAuthor%5dcauthor=truecauthor_uiditolo/pubmed/?term=Vitolo%20U%5bAuthor%5dcauthor=truecauthor_uidU1, /pubmed/?term=Botto%20B%5bAuthor%5dcauthor=truecauthor_uidotto/pubmed/?term=Botto%20B%5bAuthor%5dcauthor=truecauthor_uidB, /pubmed/?term=Capello%20D%5bAuthor%5dcauthor=truecauthor_uidapello/pubmed/?term=Capello%20D%5bAuthor%5dcauthor=truecauthor_uidD, /pubmed/?term=Vivenza%20D%5bAuthor%5dcauthor=truecauthor_uidivenza/pubmed/?term=Vivenza%20D%5bAuthor%5dcauthor