血清SccAgCA125CA199的联合检测对宫颈癌的诊断价值（基础医学范文）.docVIP

血清SccAgCA125CA199的联合检测对宫颈癌的诊断价值（基础医学范文） 文档信息 主题： 关于“医学心理学”中“妇产科学”的参考范文。 属性： F-00NZ8E，doc格式，正文4800字。质优实惠，欢迎下载！ 适用： 作为文章写作的参考文献，解决如何写好实用应用文、正确编写文案格式、内容摘取等相关工作。 作者： 佚名 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 搞要 1 关键字：宫颈癌；SccAg；CA125；CA19-9 2 [参考文献] 4 论文原创声明（模板） 6 论文致谢（模板） 7 正文 血清SccAgCA125CA199的联合检测对宫颈癌的诊断价值（基础医学范文） 搞要 摘要：目的研究血清中鳞状细胞癌抗原（squamouscellcarcinomaantigen，SccAg）、糖链抗原（carbohydrateantigen，CA）125、CA19-9这3种肿瘤标志物联合检测对宫颈癌的诊断价值。方法方便选取2009年3月―2014年5月经病理明确诊断的160例宫颈癌患者作为实验组、同期体检的160例健康人为对照组，检测血清中SccAg、CA125、CA19-9的含量，并对不同临床分期、分化程度和病理类型宫颈癌的肿瘤标志物水平进行比较；然后使用ROC曲线，检测单独及联合检测的敏感性、特异性及曲线下面积（AUC）；使用支持向量机对此诊断模型进行验证。结果宫颈癌组SccAg、CA125、CA19-9的水平显著高于正常组；宫颈癌的临床分期越高，肿瘤标志物水平也越高；宫颈癌肿瘤细胞的分化程度越高，其肿瘤标志物的水平就越低；鳞癌患者SccAg显著高于腺癌患者，而鳞癌患者CA125和CA19-9均显著低于腺癌患者，差异均有统计学意义（P）；3种肿瘤标志物联合检测效果要稍优于单独检测结果；支持向量机验证该诊断模型的准确率%。结论肿瘤标志物的高低可作为一个辅助指标来衡量肿瘤的恶性程度，SccAg、CA125、CA19-9联合检测对宫颈癌的诊断具有一定的价值 关键字：宫颈癌；SccAg；CA125；CA19-9 [中图分类号] [文献标识码] A [文章编号] 1674-0742（2016）05（b）-0075-04 [Abstract] Objective To research the diagnostic value of the combined detection of the three tumor markers including squamous cell carcinoma antigen， carbohydrate antigen and CA19-9 in serum for cervical carcinoma. Methods 160 cases of patients with cervical carcinoma definitely diagnosed by pathology from March 2009 to May 2014 were selected as the experimental group， and 160 healthy people receiving physical examination at the same period were selected as the control group， and the contents of SccAg， CA125 and CA19-9 in serum were detected， the tumor mark levels of cervical carcinoma of different clinical stages， differentiation degrees and pathologic types were compared， and then the sensitivity， specificity and area under curve of the single and combined detections were detected by ROC curve， and the diagnostic model was verified by support vector machine. Results The SccAg， CA125 and CA19-9 levels in the cervical carcinoma group were obviously higher than those in the normal group， the higher the clinical stage， the hig