临床生物化学：第十三章 脂蛋白代谢紊乱的生物化学检验.pptVIP

调整了幻灯顺序，将原幻灯第26张提前，与教材尽量保持一致，但由于字数太多,现拆分为两张. * 分子量为220KD的描述比22万要正式 * 对文字的显示顺序进行了调整 * * * Structure of HDL Particle The function of lipoproteins is to transport cholesterol and triglycerides (TGs) in the blood. The five major families of lipoproteins are: chylomicrons, very-low-density lipoproteins (VLDLs), low-density lipoproteins (LDLs), intermediate-density lipoproteins (IDLs), and high-density lipoproteins (HDLs). HDL is the smallest lipoprotein and contains the least amount of lipid. This slide shows the structure of this lipoprotein particle. HDL contains a lipid core of cholesteryl esters (CEs) and TGs surrounded by phospholipids and specialized proteins known as apolipoproteins (apos). Apos are required for the structural integrity of lipoproteins and direct their metabolic interactions with enzymes, lipid transport proteins, and cell-surface receptors (as described in subsequent slides). ApoA-I is a major component of all HDL particles and is synthesized in the liver and intestine (see next slide). ApoA-II, the second most abundant apolipoprotein in HDL, is synthesized in the liver; its function is unclear. ? References: Havel RJ, Kane JP. Introduction: structure and metabolism of plasma lipoproteins. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic and Molecular Bases of Inherited Disease. 7th ed. New York: McGraw-Hill; 1995:1841–1851. Breslow JL. Familial disorders of high-density lipoprotein metabolism. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic and Molecular Bases of Inherited Disease. 7th ed. New York: McGraw-Hill; 1995:2031–2052. Production of HDL by Liver and Intestine High-density lipoprotein (HDL) particles are formed in plasma from the coalescence of individual phospholipid-apolipoprotein complexes. HDL and its major apolipoprotein, apoA-I, are synthesized by both the liver and the intestine. The other primary apolipoprotein, apoA-II, is synthesized only by the liver. ? References: Eisenberg S. Hig