慢性阻塞性肺病合并Ⅱ型呼吸衰竭无创呼吸机联合氧气驱动雾化吸入效果评价.docxVIP

PAGE PAGE 1 慢性阻塞性肺病合并Ⅱ型呼吸衰竭无创呼吸机联合氧气驱动雾化吸入效果评价 　　 　　彭晓卉 　　 　　 　　【摘要】目的 探討慢性阻塞性肺病（COPD）合并Ⅱ型呼吸衰竭患者应用无创呼吸机联合氧气驱动雾化吸入的临床效果。方法 选取我院2021年04月～2021年10月呼吸内科收治的48例COPD合并Ⅱ型呼吸衰竭患者，依收治顺序随机为对照组（n=24）和观察组（n=24）。对照组在常规治疗基础上采用暂停无创呼吸机后行雾化吸入治疗方法，观察组在常规治疗基础上实施无创呼吸机联合氧气驱动雾化吸入治疗。对比两组雾化治疗前和治疗3d后的临床相关指标和治疗期间不良反应及舒适度（GCQ）评价。结果 治疗前，两组血气分析、肺功能指标均无明显差异，差异无统计学意义（P0.05）;治疗3d后，两组血气分析、肺功能指标较治疗前改善明显，其中，观察组改善幅度明显优于对照组。治疗期间，观察组出现口干、咽痛、排痰困难、雾化吸入不耐受不良反应例数明显少于对照组，观察组GCQ评价优于对照组，差异有统计学意义（P005）。结论 无创呼吸机联合两种不同雾化方式均适于COPD合并Ⅱ型呼吸衰竭患者临床使用，但无创呼吸机联合氧气驱动雾化吸入治疗的临床疗效更为显著，患者治疗期间不良反应少，舒适感及耐受性更好，更适于临床应用。 　　【关键词】COPD;呼吸衰竭;雾化治疗;肺功能;血气;不良反应;舒适度 　　【中图分类号】R563 【文献标识码】A 【文章编号】ISSN.2095.6681.2021.34..02 　　【Abstract】Objective To explore the clinical effect of non-invasive ventilator combined with oxygen-driven nebulization inhalation in patients with chronic obstructive pulmonary disease （COPD） combined with type Ⅱ respiratory failure.Methods Forty-eight patients with COPD combined with type Ⅱ respiratory failure who were admitted to the Department of Respiratory Medicine from April 2021 to October 2021 in our hospital were randomly selected as the control group （n = 24） and the observation group （n = 24） in the order of admission. The control group used nebulized inhalation therapy after suspending the non-invasive ventilator on the basis of conventional treatment，and the observation group implemented non-invasive ventilator combined with oxygen-driven nebulization inhalation on the basis of conventional treatment.The clinically relevant indicators and the adverse reactions and comfort （GCQ） evaluations during the treatment were compared before and after 3 days of treatment.Result Before treatment，there was no significant difference in blood gas analysis and pulmonary function indexes between the two groups （P 0.05）.After 3 days of treatment， blood gas analysis and lung function indexes of the two groups improved significantly compared with before treatment. Among them，the observation group was significantly better t