外科治疗缺血性心力衰竭stich研究概要.pptVIP

外科治疗缺血性心力衰竭STICH研究概要 外科治疗缺血性心力衰竭STICH研究概要 STICH Financial Disclosures Original Recipient Institution Principal Investigator Activity Duke University Medical Center Robert H. Jones Clinical Coordinating Ctr Duke University Medical Center Kerry L. Lee Statistical and Data CC Duke University Medical Center Daniel B. Mark EQOL Core Laboratory Univ of Alabama-Birmingham Gerald M. Pohost CMR Core Laboratory Mayo Clinic Jae K. Oh ECHO Core Laboratory University of Pittsburgh Arthur M. Feldman NCG Core Laboratory Northwestern University Robert O. Bonow RN Core Laboratory Washington Hospital Center Julio A. Panza DECIPHER Substudy Baylor University Medical Ctr Paul Grayburn MR TEE Substudy Funding Sources: National Heart, Lung and Blood Institute 97.3% Chase Medical 0.3% Abbott Laboratories 2.3% CV Therapeutics 0.1% Core STICH Study Organization Principal Investigator: Robert H Jones Co-Principal investigator: Eric Velazquez DCC Principal Investigator: Kerry L Lee Study Chair: Jean L Rouleau Executive Committee: Robert H Jones, Eric Velazquez, Kerry L Lee, Jean L Rouleau, Patrice Desvigne-Nickens, George Sopko, Chris O’Connor, Robert Michler, and Jae Oh. DSMB chair: Sid Goldstein Publications Committee chair: James Hill Clinical Endpoints Committee: Peter Carson Hypothesis 2 Enrollment by Country ? 1000 patients ? 96 clinical sites ? 23 countries ? 1231 days Randomized Patients Numbers for Analysisby Hypothesis MED+CABG (610) MED+CABG (499) CAD, EF ? 0.35 Eligible for MED-only treatment? Eligible for SVR? Not in trial No Hypothesis 1n = 1212 Hypothesis 2n = 1000 MED (602) MED+CABG+SVR (501) Stratum An = 1061 1 MED (527) 2 MED+CABG (534) Eligible for SVR? Stratum Cn = 859 Yes 6 MED+CABG (423) 7 MED+CABG+SVR (436) Stratum Bn = 216 3 MED (75) 5 MED+CABG+SVR (65) 4 MED+CABG (76) + 2136 Randomized pts = + + 602 MED only 1033 CABG added 501 CABG + SVR added = + No Yes Yes No Hypothesis 2 Surgical v