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迷迭香酸的构建Metabolic Engineering of Saccharomyces cerevisiae for Rosmarinic Acid Production.pdf

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/synthbio Research Article Metabolic Engineering of Saccharomyces cerevisiae for Rosmarinic Acid Production Mahsa Babaei, Gheorghe M. Borja Zamﬁr, Xiao Chen, Hanne Bjerre Christensen, Mette Kristensen, Jens Nielsen, and Irina Borodina * Cite This: ACS Synth. Biol. 2020, 9, 1978−1988 Read Online Metrics More Article Recommendations sı Supporting Information ACCESS * . ). s e C l T c i t U r ABSTRACT: Rosmarinic acid is a hydroxycinnamic acid ester ( a 4 d commonly found in the Boraginaceae and Lamiaceae plant families. 2 e : h 0 s It exhibits various biological activities, including antioxidant, anti- 5 i : l 0 b 0 u inﬂammatory, antibacterial, antiallergic, and antiviral properties. t p a e 1 r Rosmarinic acid is used as a food and cosmetic ingredient, and a 2 h several pharmaceutical applications have been suggested as well. 0 s 2 y 5, l Rosmarinic acid is currently produced by extraction from plants or e 2 t y a chemical synthesis; however, due to limited availability of the plant r m a i t u i sources and the complexity of the chemical synthesis method, there n g a e l J o is an increasing interest in producing this compound by microbial n t o w fermentation. In this study, we aimed to produce rosmarinic acid by H o C