制药设备请验验证专题知识分享.pptxVIP

2014.12.30;讲解纲要;关键名词解析;1.清洁工艺开发;1.清洁工艺开发;1.清洁工艺开发;1.清洁工艺开发;1.清洁工艺开发;1.清洁工艺开发;1.清洁工艺开发;1.清洁工艺开发;1.3.7 清洁工艺参数选择 清洁工艺开发中需要考虑的因素和工艺参数 nature and strength of the interactions between the product and the surface 反应物与设备表面的相互作用 Nature of the interaction between the cleaning agent and the soil 清洁剂与土壤的反应作用 Time (dirty hold time, time for each cleaning cycle) 时间（污染物持续时间，清洗周期） cleaning agent and concentration 清洁剂及浓度 ;temperature; cleaning action (flow properties(stagnant, lamnar, turbulent)and pressure) 温度，清洗操作（流动性质（停滞、层流、湍流）和压力） properties of the cleaning solution (such as ionic strength