儿童ebv感染及相关疾病的诊断讲谢正.pptVIP

慢性活动性EBV感染 第三十页，共61页 CAEBV is characterized by severe, chronic or recurrent infectious mononucleosis-like symptoms after a primary EBV infection, and has a high morbidity and mortality from hepatic failure, lymphoma, sepsis, or hemophagocytic syndrome. 1. Unusual pattern of anti-EBV antibodies (high levels of IgG anti-VCA and EA, absence of anti-EBNA) High EBV viral load in peripheral blood Clonal expansion of EBV-infected T cells and NK cells 第三十一页，共61页 Historical milestones of CAEBV 1948, Issacs: prolonged fever, malaise, lymphadenopathy, hepatosplenomegaly 1975, Horwitz et al