环孢素A慢性肾毒性及丹参保护作用.docVIP

环孢素A慢性肾毒性及丹参保护作用 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：环孢素A慢性肾毒性及丹参保护作用 1 1 材料与方法 3 2 结果 4 22 用药前后各组大鼠FENa及NAG结果（表2） 5 3 讨论 5 文2：环孢素A慢性肾毒性及丹参保护作用 6 1; 材料与方法 8 参考文摘引言： 9 原创性声明（模板） 11 文章致谢（模板） 11 正文 环孢素A慢性肾毒性及丹参保护作用 文1：环孢素A慢性肾毒性及丹参保护作用 Cyclosporin-induced chronic nephrotoxicity and preventive effects of salvia compound Abstract： Objective To explore the mechanism of cyclosporin-induced chronic nephrotoxicity and the preventive effects of salvia Thirty adult male rats were randomly allocated into 3 A received olive oil as rats in group B received cyclosporin A (CsA) and glucose rats in group C received CsA and compound salvia amounts of urine in 24 hou and renal function were measured before and after the drugs were levels of plasma renin activity(PRA),plasma angioteion II (Ang II) and Aldosterone(ALD) were also measured after the rats were given CsA and compound salvia injection for 28 days,and also the changes of renal tissues were assessed by histological CsA can induce the decrease of glomerular filtration rate (GFR) ,increase the excretion of n-acetyl-β-d-glucosaminidase（NAG）in urine ,and increase the levels of PRA and Ang II in blood obviously ,and induce the tubulointetitial fibrosis and the injury of renal arterioles .But salvia compound can decrease the levels of PRA and Ang II,improve the function of kidneys and the pathological changes .There was not significant difference in ALD levels among 3 Cyclosporin-induced chronic nephrotoxicity may be related to the activation of renin-angiotein system (RAS) ,especially to the increase of AngⅡ compound can decrease the levels of PRA and AngⅡ,and have preventive effects on chronic nephrotoxicity. Key words：cyclospori;drug toxicity;salvia compound 环孢素A(cyclosporin A,CsA)是目前器官移植术后广泛使用的免疫抑制剂，但肾毒性是限制其临床应用的主要副作用。拮抗CsA引起的肾间质纤维化，是器官移植后保障患者长期存活的重要措施之一。慢性肾毒性机制目前尚不十分清楚，有报道认为，与肾素-血管紧张素系统(renin-angiotein system,RAS)密切相关〔1〕。本研究采用口服剂型CsA慢性肾毒模型，观察慢性肾毒性时肾脏功能、RAS及病理的变化，探讨慢性肾毒性的发生机制，并应用丹参为干预措施