卡泊芬净与脂质体两性霉素B在血液病患者经验性抗真菌治疗中的比较.docVIP

卡泊芬净与脂质体两性霉素B在血液病患者经验性抗真菌治疗中的比较 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：卡泊芬净与脂质体两性霉素B在血液病患者经验性抗真菌治疗中的比较 1 1 病例和方法 3 2 结果 5 3 讨论 5 文2：两性霉素B脂质体治疗白血病合并霉菌性肺炎6例 8 1 资料和方法 9 2 结果 10 3 讨论 10 参考文摘引言： 11 原创性声明（模板） 12 文章致谢（模板） 13 正文 卡泊芬净与脂质体两性霉素B在血液病患者经验性抗真菌治疗中的比较 文1：卡泊芬净与脂质体两性霉素B在血液病患者经验性抗真菌治疗中的比较 Comparison of caspofungin and liposomal amphotericin B for empirical antifungal therapy in patients with hematologic disease ABSTRACT Objective To compare the efficacy and safety of caspofungin with liposomal amphotericin B for empirical antifungal therapy of fungal infection in patients with hematologic diseases. Methods Sixty cases of patients with high risk facto of systemic fungal infectio and unexplained fever that did not respond to broadspectrum antibiotic therapy for 3～7 days were randomly divided into 2 groups. Caspofungin group (32 cases) were administered with caspofungin intravenously 70 mg on day 1 and 50 mg once daily thereafter compared with patients in the other group (28 cases) receiving liposomal amphotericin B, 3 mg/(kg·d). Both of the treatments were continued until five days after neutropenia and fever had resolved or the drug had been administered for at least 10 days. Advee events and the efficacy were investigated. Results For caspofungin group (n=32) and liposomal amphotercin B group the overall effective rates were % and %, and the advee reactio rates were % and %, respectively. There were no significant differences in the overall effective rates between two groups, but the advee reactio occurrence of caspofungin group was lower than liposomal amphotericin B group. Conclusio Caspofungin is as effective as liposomal amphotericin B and with fewer AD in the treatment of fungal infection in patients with hematologic diseases. KEY WORDS Caspofungin; Amphotericin B; Liposomes; Fungal infection 近年来，临床观察显示侵袭性真菌感染的比例有逐渐增高的趋势，已成为造血干细胞移植、脏器移植以及其他免疫缺陷患者治疗过程中最主要的障碍之一。治疗侵袭性真菌感染的药物选择有限，疗效不理想。卡泊芬净是近年来应用于临床的一种新型抗真菌药［1］，国内临床应用的报道较少。本研究比较了卡