老年高血压患者脉压与肱动脉内皮功能变化的相关性研究.docVIP

老年高血压患者脉压与肱动脉内皮功能变化的相关性研究 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：老年高血压患者脉压与肱动脉内皮功能变化的相关性研究 1 1　临床资料 2 2　方法 3 3　结果 5 4　讨论 6 文2：老年高血压患者脉压与心脑血管事件的临床研究 7 1 资料与方法 7 2 结果 8 3 讨论 9 参考文摘引言： 9 原创性声明（模板） 10 文章致谢（模板） 11 正文 老年高血压患者脉压与肱动脉内皮功能变化的相关性研究 文1：老年高血压患者脉压与肱动脉内皮功能变化的相关性研究 The Research of Correlation Between Pulse Pressure and Endothelial Function of brachial Artery in the Elderly Patients with Essential Hyperteion Abstract: Objective To explore the correlation between pulse pressure(PP) and endothelial function of brachial artery in elderly patients with essentialwere selected，anddivided into four groups according to mode ultrasound was applied to scanthe diameterofbrachial artery at rest and reactive hyperemia caused by flowdependent dilation and afte sublingual glyceryltrinitrate induced by endotheliumindependent di1atation. Then the diameter changes of brachia1 artery were compared between the four groups. Results The bigger PP, the less disteibility coefficient and crosssectional compliance and the bigger rigidity index of brachial artery in elderly patients with essential hyperteion. There were significantdifferences in the FMD between the four group(P)．PP had a strong correlativity with FMD , the bigger PP，the less FMD(r＝-，P). Conclusion There was close relatiohip between PP and endothelial functionof brachial artery and PP was a more effective index to evaluate and forecastendothelial function of artery in patients with essential hyperteion. Key words：Hyperteion; Pulse pressure; Endothelial function; Ultrasound graphy; brachial artery; Correlation 原发性高血压是常见的疾病，是严重心脑血管事件的危险因素之一，严重危害人类的健康。脉压(pusle pressure , PP)是收缩压和舒张压之差值，是心血管事件的独立危险因子，与心血管事件危险性呈正相关，比动脉平均压、收缩压、舒张压在预测心血管事件危险性方面临床意义更大［1，2］。本研究以通过无创性的高频超声检测方法探讨老年高血压患者脉压与肱动脉内皮功能变化的相关性。 1　临床资料 门诊或住院的原发性高血压患者160 例，所有病例均符合高血压病诊断的国际统一标准，年龄52岁～78岁，平均(±)岁，其中男性84例，女性76例。所有患者至少2周内未服降压药物，以及其他 文献 提出可影响内皮功能的药物(左旋精氨酸、硝酸酯类药物和维生素C、雌激素等)，除外继发性高血压、合并瓣膜病、糖尿病、结缔组织疾病、外周血管疾病、高脂血症，高血压严重并发症：肾功能不全、心功能