焦炉工人外周血淋巴细胞HSP72表达特征医学.docVIP

焦炉工人外周血淋巴细胞HSP72表达特征医学 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：焦炉工人外周血淋巴细胞HSP72表达特征医学 1 1 对象与方法 3 12 方法 3 2 结果 5 23 焦炉工人外周血淋巴细胞HSP72表达水平 5 3 讨论 7 文2：焦炉工人外周血淋巴细胞HSP72表达特征 8 1对象与方法 9 12方法 9 23焦炉工人外周血淋巴细胞hsp72表达水平 11 参考文摘引言： 14 原创性声明（模板） 15 文章致谢（模板） 15 正文 焦炉工人外周血淋巴细胞HSP72表达特征医学 文1：焦炉工人外周血淋巴细胞HSP72表达特征医学 Expressive characte of HSP72 in peripheral blood lymphocyte of coke oven worke Abstract： Objective To investigate heat shock protein 72 (HSP72) levels in peripheral blood lymphocytes of coke oven worke and influence Two hundred sixtyseven coke oven worke and thirty controls without occupational PAHs exposure were (a)pyrene〔B(a)p〕concentratio in the ambient air were assayed by high performance liquid chromatography(HPLC).HSP72 levels in peripheral blood lymphocytes were measured by Westem information was collected by HSP72 levels in oven-top,oven-side worke(120±047，130±037) were significantly higher than that in control(085±034,P),and HSP72 levels in oven-side worke were significantly higher than those in oven-bottom worke(101±035，P005).〔B(a)p〕 concentratio and HSP72 levels in different exposed groups showed binomial distribution(R2=09999).The logistic regression analysis showed that the coke oven worke had significantly higher risk in HSP72 rising(adjust OR=131)than control,and the adjust OR of oven-top，oven-side worke were respectively 149 and linear regression result presented that in the lower exposure group(oven-bottom worke and control),smoking and drinking were inhibiting facto to HSP72 expression(the regression coefficient were respectively -00001 and -005,P005).Conclusion The coke oven emissio can induce the rising of HSP72 the high dose coke oven emissio showed inhibition to and drinking played an inhibitional role in HSP72 expression in lower exposure group. Key words： coke oven emission;polycyclic aromatic hydrocarbo;benzo(a)pyrene;heat shock protein 72;influence factor 热休克蛋白是生物体细胞在一系列应激因素作用下产生的具有高度保守性的一组细胞保护性蛋白质，