夏至草醇提物干预实验性弥散性血管内凝血大鼠肺损伤的实验研究药学.docVIP

夏至草醇提物干预实验性弥散性血管内凝血大鼠肺损伤的实验研究药学 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：夏至草醇提物干预实验性弥散性血管内凝血大鼠肺损伤的实验研究药学 1 1 器材与方法 3 2 结果 5 3 讨论 5 文2：夏至草醇提物对实验性弥散性血管内凝血大鼠心肌损伤的影响 7 1 材料和方法 8 2 结果 9 3 讨论 10 参考文摘引言： 11 原创性声明（模板） 12 文章致谢（模板） 13 正文 夏至草醇提物干预实验性弥散性血管内凝血大鼠肺损伤的实验研究药学 文1：夏至草醇提物干预实验性弥散性血管内凝血大鼠肺损伤的实验研究药学 Abstract：ObjectiveTo observe the effects of ethanol extract from Mrrubium incisum agait lung injury of disseminated intravascuclar coagulation (DIC) rats induced by Dextran male Wistar rats were randomly divided into three groups: Mrrubium incisum group (n=8), model group (n=6) and control group (n=6). The DIC model was established by intravenous injection of Dextran 500 (10 ml/kg·bw), and Dextran 500 was replaced by equivalent normal saline in control group. 6 minutes later, ethanol extract from Mrrubium incisum was infused (5 g/ml, 6g/kg·bw); in other groups ethanol extract from Mrrubium incisum was replaced by normal saline. After 40 min, the lung was taken out, the 10% tissue homogenate was prepared, and the free radical indexes of MDA content and SOD activity, NO content and NOS activity were contents of MDA and NO and NOS activity of lung homogenate in model group were significantly increased, and SOD activity were significantly lower than that in control group. The contents of MDA and NO and NOS activity of lung homogenate in Mrrubium incisum group were significantly lowered, and SOD activity were significantly increased as compared with model group. There was no statistical difference between Mrrubium incisum group and control group. ConclusionEthanol extract from Mrrubium incisum can markedly abate lung injury of DIC rats by Dextran 500 and its mechanism may be related to scavenging free radical and decreasing NO release. Key words：Mrrubium incisum; Disseminated intravascuclar coagulation (DIC); Dextran 500; Lung injury; Free radical; Nitric oxide 弥散性血管内凝血（disseminated intravascuclar coagulation, DIC）是临床常见的危重病理过程，在此病理过程中所形成的微血栓、以及