波立维治疗急性冠脉综合征的效果分析.pptVIP

* * 因此，对于药物治疗ACS患者，应在入院后尽早给予波立维300mg负荷剂量，从而尽快降低缺血性事件危险；随后继以75mg/日维持剂量至少12个月，保障长期持续获益。 * * * * * Reference: 1. Data on file, Sanofi-Synthélabo 1999, internal report PDY 3494. A loading dose of clopidogrel provides rapid and full effect by 3 hours and was very well tolerated. A study of healthy volunteers demonstrated that the rapid inhibition of platelet aggregation was achieved with a 300 mg dose of clopidogrel alone. The full antiplatelet affect (ADP platelet inhibition between 60–80%) was achieved within 3 hours and a significant effect was seen within the first 1.5 hours.* *At 24