胃肠道恶性神经外胚层肿瘤临床病理分析及文献复习.docVIP

胃肠道恶性神经外胚层肿瘤临床病理分析及文献复习 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：胃肠道恶性神经外胚层肿瘤临床病理分析及文献复习 1 3文献复习 5 文2：宫颈息肉样病变与肿瘤临床病理分析 7 1 资料与方法 8 1．1 临床资料 8 1．2 方法 8 2 结果 8 3 讨论 10 参考文摘引言： 11 原创性声明（模板） 12 文章致谢（模板） 12 正文 胃肠道恶性神经外胚层肿瘤临床病理分析及文献复习 文1：胃肠道恶性神经外胚层肿瘤临床病理分析及文献复习 [Abstract]Objective To investigate clinicopathological features，immunophenotype，molecular genetics and differential diagnosis of malignant gastrointestinal neuroectodermal A case of rare malignant gastrointestinal neuroectodermal tumor in December 2015 in our hospital was analyzed and reviewed the related histological and immunohistochemical results were observed，and the fusion status of EWSR1 gene was detected by fluorescence in situ hybridization （FISH）.Results The tumor was located in the small intestine，the poor-circumscribed lesion located in the entire thickness of the bowel wall extending into the mucosal layer with a significant infiltrative growth tumo cells composed of round，short spindle or round epithelium-like cells arranged in sheets or number of multinucleated osteoclast-like giant cells had also been nuclei that was surrounded by variable amounts of eosinophilic cytoplasm showed vesicular chromatin with generally distinct to nucleoli and variable mitotic activity were easy to tumor cells were strongly positive for S-100 and Vimentin，and positive for CD99，CD56 and Syn，and weak positive for CR，the Ki-67 proliferating index was about 30% in the aspect of in situ hybridization results showed EWSR1 gene Malignant gastrointestinal neuroectodermal tumor is an additionally rare tumor with high aggressive and poor definite diagnosis for it mainly depends on the histology，immunophenotype，at the same time，need to be differentiated from other malignant rearrangement analysis of EWSR1 gene is helpful for pathologic diagnosis。 [Key words]Malignant neuroectodermal tumor；Immunophenotype；Molecular genetics 原发性胃肠道间叶性肿瘤大多数是胃肠道间质瘤（gastrointestinal stromal tumor，GIST），而近年来文献报道了