教授炎症与组织再生.pptx

Inflammation Tissue Regeneration;;;Inflammation;Causes of inflammation;外源性;Local symptoms of inflammation;Inflammation;; ;渗出白细胞各类：;定义：炎症局部细胞的快速复制 成分： 1） 实质细胞：各器官的功能细胞（肝细胞、腺上皮细胞） 2）间质细胞: 纤维母细胞、血管内皮细胞 3）炎症细胞: 巨噬细胞、淋巴细胞 功能： 1） 限制炎症的进一步播散 2）修复;Types of inflammation;中性粒细胞 （ neutrophils，polymorphonuclear neutrophils or PMNs ）;巨噬细胞 (macrophage);淋巴细胞(lymphocyte);Development of acute inflammation;(1) 血管口径和血流速度的改变 ;;1) 游出 边集和滚动 黏附 游出：阿米巴运动 2) 在损伤部位聚集 趋化作用 3) 吞噬和杀伤反应;白细胞的渗出;趋化作用（ Chemotaxis ）;Inflammation;(3) 杀伤和降解： 氧爆发过程：NADPH 氧化酶活化，生成O-, H2O2 , HOCL. ; e of acute inflammation; e of acute inflammation;The intensity and duration of the response depend on: severity of injurious agent reactive capability of host;Science, 2012. 338(6112): p. 1353-6.;炎症反应对于组织发育，机体的内稳态以及损伤修复均具有重要作用;Tissue Regeneration;组织再生的发生过程 Processes of tissue regeneration;The comparison of regeneration between skeletal muscle and the CNS;Immune cell polarization are key components of tissue repair or regeneration;在成年的哺乳动物的心脏（缺乏再生能力）中包括各种类型的心脏巨噬细胞，这些细胞发挥不能的功能，具有不同的分化来源以及不能的维持稳态的机制。;;;Tissue Regeneration;Mesenchymal Stem Cells (MSCs);Cell Res. 2010;1、Characterization of MSCs;2、Therapy effect of MSCs on FHF ;3、Effect of MSCs on pathogenic CD4+ T cells ;3、Effect of MSCs on pathogenic CD4+ T cells ;3、Effect of MSCs on pathogenic CD4+ T cells ;3、Effect of MSCs on pathogenic CD4+ T cells ;;4、Effect of MSCs on dendritic cells (DCs);4、Effect of MSCs on DCs;;4、Effect of MSCs on DCs;4、Effect of MSCs on DCs;;5、Effect of MSCs on DC precursors;;;5、Effect of MSCs on DC precursors;;Autophagy of MSCs in vivo;Autophagy;7、Proinflammatory cytokines induce autophagy of MSCs;E;8、Autophagy reduces immunotherapeutic effect of MSCs ;9、Pharmaceutical inhibition of autophagy improves the therapeutic efficacy of MSCs in EAE;;Tissue Regeneration;谢谢！