免疫学免疫不知名课件9.hypersensitive reactions.pptxVIP

Hypersensitive Reactions超敏反应;;;Definition of hypersensitivity;Types of hypersensitive responses;Types of hypersensitive responses;Types of hypersensitive responses; IgE-Mediated (Type I) Hypersensitivity Antibody-Mediated Cytotoxic (Type II) Hypersensitivity Immune Complex–Mediated (Type III) Hypersensitivity Type IV or Delayed-Type Hypersensitivity (DTH);Components of Type I Reactions;IgE-Mediated (Type I) Hypersensitivity;IgE-Mediated (Type I) Hypersensitivity;IgE-Mediated (Type I) Hypersensitivity;normal humoral response;General mechanism underlying a type I hypersensitive reaction.; 1. 过敏性休克 （1）药???过敏性休克; （2）血清过敏性休克； 2.呼吸道过敏反应：过敏性鼻炎、支气管哮喘 3.消化道过敏反应 4. 皮肤过敏反应 * 变应原皮肤试验;Asthma ;asthma?is complex and involves airway inflammation, intermittent airflow obstruction, and bronchial hyperresponsiveness. Asthma cannot be cured, but it can be controlled; IgE-Mediated (Type I) Hypersensitivity Antibody-Mediated Cytotoxic (Type II) Hypersensitivity Immune Complex–Mediated (Type III) Hypersensitivity Type IV or Delayed-Type Hypersensitivity (DTH);Antibody-Mediated Cytotoxic (Type II)Hypersensitivity;Antibody-Mediated Cytotoxic (Type II)Hypersensitivity;;;;Three examples of type II hypersensitive reactions;Transfusion Reactions;ABO blood group system;ABO blood group system;Hemolytic Disease of the Newborn;;Drug-Induced Hemolytic Anemia; IgE-Mediated (Type I) Hypersensitivity Antibody-Mediated Cytotoxic (Type II) Hypersensitivity Immune Complex–Mediated (Type III) Hypersensitivity Type IV or Delayed-Type Hypersensitivity (DTH);Immune Complex–Mediated(Type III) Hypersensitivity;血液循环中的可溶性抗 原与相应的抗体(IgG、IgM 类）结合形成可溶性的免疫 复合物，在一定条件下积于 组织，通过激活补体并在血 小板、中性粒细胞等其它细 胞的参与下，引起组织损 伤的过程。;Definition 血液循环中的可溶性抗原与相应的抗体(IgG、IgM 类）结合形成可溶性的免疫复合物，在一定条件下积于组织，通过激活补体并在血小板、中性粒细胞等其它细胞的参与下，引起组织损伤的过程。;Antigens * 内源性抗原：变性IgG；核抗原；肿瘤抗原 * 外源性抗原：微生物、寄生虫、药物和异 种血清等 ;Immune Complex–Mediated(Type III) Hyperse