不同抗原诱导不同动物多发性硬化模型的比较（医疗卫生论文资料）.docVIP

不同抗原诱导不同动物多发性硬化模型的比较（医疗卫生论文资料） 文档信息 ： 文档作为关于“医学心理学”中“兽医”的参考范文，为解决如何写好实用应用文、正确编写文案格式、内容素材摘取等相关工作提供支持。正文11744字，doc格式，可编辑。质优实惠，欢迎下载！ 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：不同抗原诱导不同动物多发性硬化模型的比较 2 1 材料与方法 3 2 结 果 7 3 讨 论 9 文2：不同方法治疗异位妊娠比较 12 1 资料与方法 12 1．2 方法 13 1．4 统计学方法 采用χ 2 检验。 13 2 结果 13 参考文摘引言： 16 原创性声明（模板） 17 文章致谢（模板） 18 正文 不同抗原诱导不同动物多发性硬化模型的比较（医疗卫生论文资料） 文1：不同抗原诱导不同动物多发性硬化模型的比较 Comparison of Various Animal Models of Multiple Sclerosis Induced by Different Antige on Different Animals LU Zheng-qi， ZHU Can-sheng， ZHENG Xue-ping， WANG Dun-jing， HU Xue-qiang ( Department of Neurology， The Third Affiliated Hospital of SUN Yat-sen Univeity， Guangzhou 510630， China ) Abstract： 【Objective】 To compare neurofunctional impairment and pathological features of various animal models of multiple sclerosis (MS)-experimental autoimmune encephalomyelitis (EAE)-induced by different antige on different animals. 【Methods】 C57BL/6 mice EAE model， DA rat EAE model and cynomolgus monkeys EAE model were induced by MOG 35-55 peptide， guinea pig spinal cord homogenate (GPSCH) and cerebral white matter homogenate (CWMH) emulsified with complete Freund′s adjuvant (CFA)， respectively. Neurofunctional scores were recorded. Tissues were sectioned and stained with hematoxylin and eosin (HE) for revealing inflammatory infiltrates. Solochrome cyanin technique or Luxol fast blue staining was used for myelin staining， and Bielschowsky′s staining for axonal damage. Ultrastructure was observed by electronic microscope. 【Results】 EAE models were successfully induced by all methods mentioned above. The morbidity of all the experimental animals was 100%. However， C57BL/6 mice EAE model immunized with MOG 35-55 peptide was chronic and progressive， with mild inflammation， obvious demyelination and axonal loss. DA rat EAE model was acute， with severe inflammation and mild demyelination. Cynomolgus monkeys EAE model was veatile， with acute， chronic relapsing and progre