负压封闭吸引联合血管保护套对裸露血管和创面修复的作用.docxVIP

负压封闭吸引联合血管保护套对裸露血管和创面修复的作用 　　【摘要】目的：探讨负压封闭吸引联合血管保护套对兔下肢裸露血管的保护作用及创面修复影响。方法：取健康清洁级新西兰兔30只，将其按随机数字表法分为三组，分别为模型对照组、负压吸引组、联合治疗组，每组10只。血管裸露创面模型造模成功后，模型对照组常规换药包扎。负压吸引组予以-100mmhg压力吸引，联合治疗组予以-100mmhg压力加血管保护套吸引，分别在3d和7d后比较各组创面愈合率和心肌收缩舒张能力，并在7d后比较负压吸引组和联合治疗组的血管受压情况。结果：3d和7d后联合治疗组的创面愈合率比另两组更高，且7d后的创面愈合率高于3d后的，差异均有统计学意义（p0.05）。心肌收缩舒张影响，3d和7d后分别与模型对照组相同时间点比较，+dp/dtmax和-dp/dtmax高，且3d后的变化速率更高，差异均有统计学意义（p0.05）。血管受压情况，7d后负压吸引组血管创伤充血明显，血管壁相对狭窄畸形，联合治疗组血管完好通畅，血管壁未见损伤。结论：负压封闭吸引联合血管保护套可有效避免裸露血管受压，降低对心肌收缩舒张能力的影响，并可加速创面修复。 　　【关键词】负压封闭吸引血管保护套裸露血管創面修复 　　[abstract]objective：tostudytheprotectiveeffectofvacuumsealingdrainagecombinedwithvascularprotectivecoverontheexposedbloodvesselsofrabbitlowerlimbsandtheeffectofwoundhealing.method：thirtyhealthynewzealandrabbitswereselectedandrandomlydividedintothreegroupsaccordingtotherandomnumbertablemethod.theywerethemodelcontrolgroup，thevsdgroupandthecombinedtreatmentgroup，with10ineachgroup.aftersuccessfulmodelingofthevesselexposedwoundmodel，routinedressingdressingwasappliedtothemodelcontrolgroup.thevsdgroupwasgiven-100mmhgpressuresuction，thecombinedtreatmentgroupwasgiven-100mmhgpressureplusvascularprotectivecoversuction.after3dand7d，thewoundhealingrateandmyocardialsystolicanddiastolicabilityofeachgroupwerecompared.after7d，thevascularcompressioninthevsdgroupandthecombinedtreatmentgroupwascompared.result：after3dand7d，thewoundhealingrateofthecombinedtreatmentgroupwerehigherthanthatoftheothertwogroups，andthewoundhealingrateafter7dincreasedmorethanthatafter3d，withstatisticallysignificantdifferences（p0.05）.myocardialsystolicanddiastoliceffectsinthecombinedtreatmentgroupcomparedwiththemodelcontrolgroupatthesametimepointafter3dand7d，+dp/dtmaxand-dp/dtmaxincreased，andthechangerateafter3dwashigher，withstatisticallysignificantdifferences（p0.05）.after7d，thenegativepressuresuctiongrouphadobviousvasculartraumaandcongestion，hecombinedtreatmentgroup，thevesselswereintactandunobstructed，withnodamagetothevascularwall.conclusion：vsdcombinedwithvascularprotectivec