医学免疫学：免疫缺陷病2017.pptVIP

* In HIV infection, the virus replicates mainly in the activated cells. and these infected cells die quickly, hence the rapid decay rate a. The virus does not replicate well in resting T cells * However, one rare occasions some of the activated T cells can become infected as they are in the process of returning to a resting state. This results in a stably integrated form of the viral genome in a memory T cell, a cell population with a very low decay rate. And what is particularly interesting is that as the cell undergoes this profound change from an activated to a resting state, HIV gene