Anti-Influenza-agent-4-DataSheet-生命科学试剂-MCE.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Anti-Influenza agent 4 Cat. No.: HY-148309 CAS No.: 522625-85-0 分⼦式: C₁₉H₁₈N₂O₅S 分⼦量: 386.42 作⽤靶点: Influenza Virus 作⽤通路: Anti-infection 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 Anti-Influenza agent 4 是⼀种有效且具有选择性的流感病毒 (influenza virus) 抑制剂，对 A/Roma 和 A/Parma 毒株的 EC50 分别为 150 nM 和 62 nM。 IC50 Target EC50: 150±0.07 nM (A/Roma), 62±0.02 nM (A/Parma) [1] 体外研究 Anti-Influenza agent 4 (compound 5) (0-500 μM; 24 and 48 h) exhibits low cytotoxicity in MDCK cells [1]. Anti-Influenza agent 4 shows highly antiviral activity against influenza strain A/Roma and A/Parma with EC50s of 150±0.07 nM and 62±0.02 nM, respectively [1]. Anti-Influenza agent 4 shows IC50s of 244 nM and 230.7 nM against influenza strain A/Roma and A/Parma in hemolysis inhibition assay [1]. Cell Cytotoxicity Assay [1] Cell Line: MDCK cells Concentration: 0-500 μM Incubation Time: 24 and 48 h Result: Exhibited low cytotoxicity with a CC50 value of 450 μM. REFERENCES [1]. Agamennone M, Pietrantoni A, Supe