人类遗传病人类遗传病 (1).pdfVIP

RESEARCH REPORTS Clinical 1 2 1 Y. Gao , H. Kobayashi , and B. Ganss * The Human KROX-26/ZNF22 1Canadian Institutes for Health Research (CIHR) Group in Matrix Dynamics, University of Toronto, Faculty of Gene is Expressed at Sites Dentistry, Fitzgerald Building, Room 239, 150 College Street, Toronto, ON M5S 3E2, Canada; and 2 Tokyo of Tooth Formation and Maps Medical and Dental University, Department of Hard Tissue Engineering (Periodontology), Bunkyo-ku, Tokyo, Japan; *corresponding author, b.ganss@utoronto.ca to the Locus for Permanent Tooth J Dent Res 82(12):1002-1007, 2003 Agenesis (He-Zhao Deficiency) ABSTRACT INTRODUCTION Tooth development is mediated by sequential and he early development of teeth as an epithelial appendage progresses reciprocal interactions between dental epithelium Tthrough well-defined morphological changes, starting with the formation and mesenchyme under the molecular control of of the dental lamina as a thickened layer of dental epithelium and its secreted growth factors and responsive subsequent protrusion into underlying mesenchyme during bud, cap, and transcription factors. We have previously bell stages. During the late-cap stage, multipotential precursor cells identified the transcription factor Krox-26 as a differentiate along tooth-specific lineages and secrete components of the potential regulator of tooth formation in mice. The extracellular matrix required for formation of mineralized structures such as purpose of this study was to investigate a dentin, enamel, cementum, and bone. These morphological changes and potentially similar role for the human KROX-26 cellular activ