SHIGELLOSIS细菌性痢疾的学习课件.pptxVIP

SHIGELLOSIS细菌性痢疾的学习课件第1页/共33页 DefinitionShigellosis is an intestinal infection caused by a genus of bacteria known as Shigella that causes diarrheal disease of the colon or large intestines. 2第2页/共33页 3第3页/共33页 4Etiology Agent: genus Shigella: non-motile, non-spore-forming, Gram negative bacillus4 species: A S. dysenteriae :13B S. flexneri:6C S. boydii:18D S. sonnei:1Viability: strong,1-3weeks, sensitive to mercuric chloride,第4页/共33页 5EpidemiologySource of infection：Reservoir: Humans/primatesCarriers, chronic patients, Atypical patientsMode of TransmissionFecal-oral, Person-to-person, oral-genitalIngestion of contaminated food and/or drinkContact with contaminated inanimate objectsHouseflies第5页/共33页 EpidemiologySusceptible population:universe2nd, 3rd yearEpidemical featuresThe peak incidence is in July to October6第6页/共33页 7cell invasionIntracellular multiplyIntra and intercellular spreadHost cell killingPathogenesiscolonic epithelial cells Enterotoxin, cytotoxin, cytokine-mediated inflammation, necrosis 第7页/共33页 Pathogenesis8pathological features of the Sigmoid colon and rectumAcute period： Fibrin diffuse exudative inflammationSevere cases : pseudomembranes, Ulcerationspolymorphonuclear and mononuclear cells infiltration,Mild cases: Diffuse edema of congestive, visible mucus exudation of blood.Chronic period: Mucosal edema, bowel wall thickening, scar formation, polypformation, intestinal stricture第8页/共33页 Pathogenesis of shigellosis in humans9第9页/共33页 10Pathological features of the Sigmoid colon and rectum第10页/共33页 11Clinical ManifestationsIncubation Period Average: 1-3 (up to 4) days Range: 12 to 96 hours, up to 8 daysDisease presentation, severity, and case fatality - dependent upon:HostBacterial serotype and numbers第11页/共33页 Clinical ManifestationDisease typical Presentation: Fever, nausea, vomiting, Dysentery (blood, mucus) ,frequent, small-volume, TenesmusAbdominal pain (lower left abdominal quadrants)12第12页/共33页 Clinical Manifestation Typical